H1N1 was becoming really serious in the world including Malaysia. Here, i am posting a guidelines for antiviral treatment for H1N1. Hope it will helps for you to prevent and help to stop the spread of this dangerous virus!
As mention above, H1n1 influenza virus has now spread worldwide with over 100 countries including Malaysia. Therefore, the World Health Organization (WHO) has issued a guidelines for antiviral treatment for novel influenza A (H1N1). This guidelines provide a basis for advice to clinicians regarding the use of the currently available antivirals for patients presenting with illness causd by unfluenza infection.
Besides, in this guideline, it does highlight oseltamivir and zanamivir, wich are neuraminidase inhibitors and amantadine ad rimantadine which are M2 inhibitors. This guidelines urge country and local public health authorities to issue local recommendations for clinician periodically based on epidemiological and antiviral susceptibility data on the locally circulating influenza strains.
From the articles, the specific recommendations regarding use of antivirus for treatment of pandemic (H1N1)influenza virus infection are:
1. Oseltamivir should be prescribed and treatment started as soon as possible for ptients with severe or progressive clinical illness.
2. Higher doses of up to 150 mg twice daily and longer duration of treatment may be indicated.
3. Zanamivir is indicated for patients with severe or progressive clinical illness when oseltamivir is not available or not possible to use, or when the virus is resistant to oseltamivir but known or likely to be susceptible to zanamivir.
4. Antiviral treatment is not required in patients not in at-risk groups who have uncomplicated illness caused by confirmed or strongly suspected influenza virus infection (weak recommendation, low-quality evidence). Patients considered to be at risk are infants and children younger than 5 years of age; adults older than 65 years of age; nursing home residents; pregnant women; patients with chronic comorbid disease including cardiovascular, respiratory, or liver disease and diabetes; and immunosuppressed patients because of malignancy, HIV infection, or other diseases.
5. Oseltamivir or zanamivir treatment should be started as soon as possible after the onset of illness in patients in at-risk groups who have uncomplicated illness caused by influenza virus infection.
0 comments: